What happens when hyperintelligent roommates Sheldon and Leonard meet Penny, a free-spirited beauty moving in next door, and realize they know next to nothing about life outside of the lab. Rounding out the crew are the smarmy Wolowitz, who thinks he's as sexy as he is brainy, and Koothrappali, who suffers from an inability to speak in the presence of a woman.
- Runtime: 25 minutes
- Status: Continuing
- Jim Parsons as "Sheldon Cooper"
- Johnny Galecki as "Leonard Hofstadter"
- Kaley Cuoco as "Penny"
- Simon Helberg as "Howard Wolowitz"
- Kunal Nayyar as "Rajesh Koothrappali"
- Melissa Rauch as "Bernadette Rostenkowski"
- Mayim Bialik as "Amy Farrah Fowler"
- Laura Spencer as "Emily Sweeney"
- Alessandra Torresani as "Claire"
- Brian Thomas Smith as "Zack Johnson"
- Kevin Sussman as "Stuart Bloom"
- Sara Gilbert as "Leslie Winkle"